Protein Details: Inward rectifier potassium channel 18
Protein ID
ICDB_Pro_0098
Protein Name
Inward rectifier potassium channel 18
Gene Name
KCNJ18
Organism
Homo sapiens (Human)
Length
433 amino acids
AlphaFoldDB
AF-B7U540-F1-model_v4.pdb
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised;the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium
Sequence
MTAASRANPYSIVSLEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIAFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGVIFWVIAVAHGDLEPAEGHGRTPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECLVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGGVLEQRPYRRGSEI
PDB Structures
Ligand Binding
Binding Site
Disease
Thyrotoxic Periodic Paralysis 2 and Thyrotoxic Periodic Paralysis
Location
Specifically expressed in skeletal muscle.
DOI ID
10.1016/j.cell.2009.12.024; 10.1038/nature04689; 10.1186/s12883-015-0290-8;
RefSeq
NP_001181887.2